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recombinant human igg1 monoclonal antibody cixutumumab formerly imc-a12  (ImClone Inc)

 
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    Structured Review

    ImClone Inc recombinant human igg1 monoclonal antibody cixutumumab formerly imc-a12
    Clinical trials on targeted therapy in hepatocellular carcinoma recurrence.
    Recombinant Human Igg1 Monoclonal Antibody Cixutumumab Formerly Imc A12, supplied by ImClone Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/imc-a12+antibody/imc+a12+antibody/pmc09955633-107-0-8
    Average 90 stars, based on 1 article reviews
    recombinant human igg1 monoclonal antibody cixutumumab formerly imc-a12 - by Bioz Stars, 2026-10
    90/100 stars

    Images

    1) Product Images from "Potential Molecular Targeted Therapy for Unresectable Hepatocellular Carcinoma"

    Article Title: Potential Molecular Targeted Therapy for Unresectable Hepatocellular Carcinoma

    Journal: Current Oncology

    doi: 10.3390/curroncol30020105

    Clinical trials on targeted therapy in hepatocellular carcinoma recurrence.
    Figure Legend Snippet: Clinical trials on targeted therapy in hepatocellular carcinoma recurrence.

    Techniques Used: Clinical Proteomics, Virus, Infection

    Related Articles

    Control:

    Article Title: Insulin-like growth factor receptor signaling in breast tumor epithelium protects cells from endoplasmic reticulum stress and regulates the tumor microenvironment
    Article Snippet: IMC-A12 (10 mg/ml), a monoclonal antibody against IGF-1R, was provided by ImClone Systems, a wholly owned subsidiary of Eli Lilly and Co. Human IgG antibody (31154; 11.3 mg/ml), a monoclonal antibody used as a control, was purchased from Invitrogen.

    Article Title: Chemotherapy and targeted agents for thymic malignancies.
    Article Snippet: www.expert-reviews.com ISSN 1473-7140 © 2012 Expert Reviews Ltd 10.1586/ERA.12.29 Thymic malignancies represent a wide range of clinical, histologic and molecular entities that may be aggressive and difficult to treat [1–4].. The current histopathologic classification distinguishes thymomas (types A, AB, B1, B2 and B3) and thymic carcinoma based upon the morphology of epithelial tumor cells (with an increasing degree of atypia from type A to thymic carcinoma), the relative proportion of the nontumoral lymphocytic component (decreasing from types B1 to B3) and resemblance to normal thymic architecture [2].. Tumor invasiveness as evaluated by the Masaoka staging system is a major predictor of outcome [5,6].

    Article Title: Combination drug therapy for the treatment of solid tumors
    Article Snippet: 11:944s-950s; or being developed by Imclone (e.g., IMC-A12), or ganitumab, an anti-IGF1R antibody (Amgen), as described in “RECOMMENDED International Nonproprietary Names: List 65,” published by the World Health Organization, Avenue Appia 2, 1211 Geneva 27, Switzerland; R1507, an anti-IGF1R antibody (Genmab/Roche); AVE-1642, an anti-IGF1R antibody (Immunogen/Sanofi-Aventis); MK 0646 or h7C10, an anti-IGF1R antibody (Merck); or antibodies being develop by Schering-Plough Research Institute (e.g., SCH 717454 or 19D12; or as described in US Patent Application Publication Nos.

    Article Title: Insulin-like Growth Factor-II (IGF-II) and IGF-II Analogs with Enhanced Insulin Receptor-a Binding Affinity Promote Neural Stem Cell Expansion
    Article Snippet: In some experiments, the functional blocking antibody, IMC-A12, a monoclonal antibody against IGF-1R was used (provided by ImClone Systems, a wholly owned subsidiary of Eli Lilly and Co).

    Article Title: Compositions for the treatment of solid tumors
    Article Snippet: 11:944s-950s; or being developed by Imclone (e.g., IMC-A12), or ganitumab, an anti-IGF1R antibody (Amgen), as described in “RECOMMENDED International Nonproprietary: Names: List 65,” published by the World Health Organization, Avenue Appia 2, 1211 Geneva 27, Switzerland; R1507, an anti-IGF1R antibody (Genmab/Roche); AVE-1642, an anti-IGF1R antibody (Immunogen/Sanofi-Aventis); MK 0646 or h7C10, an anti-IGF1R antibody (Merck); or antibodies being develop by Schering-Plough Research Institute (e.g., SCH 717454 or 19D12; or as described in US Patent Application Publication Nos.

    Article Title: Circulating tumor cell assay
    Article Snippet: Other preferred anti-IGF-1R antibodies include F-50035 and MK-0646 (Pierre Fabre/Merck); 19D12 (Schering-Plough); R1507 (Roche/Genmab); EM-164/AVE-1642 (Immunogen/Sanofi-Aventis); IMC-A12 (ImClone Systems); AMG479 (Amgen); as well as antibodies described in International Patent Application No. WO2006/069202; U.S. Patent Application Publication No. 2005/0147612; U.S. Patent Application Publication No. 2005/0084906; U.S. Patent Application Publication No. 2005/0249730; U.S. Patent Application Publication No. 2004/0018191; U.S. Patent Application Publication No. 2005/0136063; U.S. Patent Application Publication No. 2003/0235582; U.S. Patent Application Publication No. 2004/0265307; U.S. Patent Application Publication No. 2004/0228859; U.S. Patent Application Publication No. 2005/0008642; European Patent Application No. 1622942; U.S. Patent Application Publication No. 2003/0165502; and U.S. Patent Publication No. 2005/0048050.

    Article Title: The Pathophysiology of Thyroid Eye Disease (TED): Implications for Immunotherapy
    Article Snippet: Figitumumab (CP-751,871) is a blocking anti-IGF-1R antibody currently undergoing phase III clinical trials in patients with non-small cell lung cancers, and IMC-A12 (Imclone), a human monoclonal antibody against IGF-1R, which has also shown promise in the treatment of other IGF-1R bearing neoplasms [ 49 , 50 ].

    Staining:

    Article Title: Insulin-like growth factor receptor signaling in breast tumor epithelium protects cells from endoplasmic reticulum stress and regulates the tumor microenvironment
    Article Snippet: IMC-A12 (10 mg/ml), a monoclonal antibody against IGF-1R, was provided by ImClone Systems, a wholly owned subsidiary of Eli Lilly and Co. Human IgG antibody (31154; 11.3 mg/ml), a monoclonal antibody used as a control, was purchased from Invitrogen.

    Article Title: Chemotherapy and targeted agents for thymic malignancies.
    Article Snippet: www.expert-reviews.com ISSN 1473-7140 © 2012 Expert Reviews Ltd 10.1586/ERA.12.29 Thymic malignancies represent a wide range of clinical, histologic and molecular entities that may be aggressive and difficult to treat [1–4].. The current histopathologic classification distinguishes thymomas (types A, AB, B1, B2 and B3) and thymic carcinoma based upon the morphology of epithelial tumor cells (with an increasing degree of atypia from type A to thymic carcinoma), the relative proportion of the nontumoral lymphocytic component (decreasing from types B1 to B3) and resemblance to normal thymic architecture [2].. Tumor invasiveness as evaluated by the Masaoka staging system is a major predictor of outcome [5,6].

    Article Title: Combination drug therapy for the treatment of solid tumors
    Article Snippet: 11:944s-950s; or being developed by Imclone (e.g., IMC-A12), or ganitumab, an anti-IGF1R antibody (Amgen), as described in “RECOMMENDED International Nonproprietary Names: List 65,” published by the World Health Organization, Avenue Appia 2, 1211 Geneva 27, Switzerland; R1507, an anti-IGF1R antibody (Genmab/Roche); AVE-1642, an anti-IGF1R antibody (Immunogen/Sanofi-Aventis); MK 0646 or h7C10, an anti-IGF1R antibody (Merck); or antibodies being develop by Schering-Plough Research Institute (e.g., SCH 717454 or 19D12; or as described in US Patent Application Publication Nos.

    Article Title: Insulin-like Growth Factor-II (IGF-II) and IGF-II Analogs with Enhanced Insulin Receptor-a Binding Affinity Promote Neural Stem Cell Expansion
    Article Snippet: In some experiments, the functional blocking antibody, IMC-A12, a monoclonal antibody against IGF-1R was used (provided by ImClone Systems, a wholly owned subsidiary of Eli Lilly and Co).

    Article Title: Compositions for the treatment of solid tumors
    Article Snippet: 11:944s-950s; or being developed by Imclone (e.g., IMC-A12), or ganitumab, an anti-IGF1R antibody (Amgen), as described in “RECOMMENDED International Nonproprietary: Names: List 65,” published by the World Health Organization, Avenue Appia 2, 1211 Geneva 27, Switzerland; R1507, an anti-IGF1R antibody (Genmab/Roche); AVE-1642, an anti-IGF1R antibody (Immunogen/Sanofi-Aventis); MK 0646 or h7C10, an anti-IGF1R antibody (Merck); or antibodies being develop by Schering-Plough Research Institute (e.g., SCH 717454 or 19D12; or as described in US Patent Application Publication Nos.

    Article Title: Circulating tumor cell assay
    Article Snippet: Other preferred anti-IGF-1R antibodies include F-50035 and MK-0646 (Pierre Fabre/Merck); 19D12 (Schering-Plough); R1507 (Roche/Genmab); EM-164/AVE-1642 (Immunogen/Sanofi-Aventis); IMC-A12 (ImClone Systems); AMG479 (Amgen); as well as antibodies described in International Patent Application No. WO2006/069202; U.S. Patent Application Publication No. 2005/0147612; U.S. Patent Application Publication No. 2005/0084906; U.S. Patent Application Publication No. 2005/0249730; U.S. Patent Application Publication No. 2004/0018191; U.S. Patent Application Publication No. 2005/0136063; U.S. Patent Application Publication No. 2003/0235582; U.S. Patent Application Publication No. 2004/0265307; U.S. Patent Application Publication No. 2004/0228859; U.S. Patent Application Publication No. 2005/0008642; European Patent Application No. 1622942; U.S. Patent Application Publication No. 2003/0165502; and U.S. Patent Publication No. 2005/0048050.

    Article Title: The Pathophysiology of Thyroid Eye Disease (TED): Implications for Immunotherapy
    Article Snippet: Figitumumab (CP-751,871) is a blocking anti-IGF-1R antibody currently undergoing phase III clinical trials in patients with non-small cell lung cancers, and IMC-A12 (Imclone), a human monoclonal antibody against IGF-1R, which has also shown promise in the treatment of other IGF-1R bearing neoplasms [ 49 , 50 ].

    Transfection:

    Article Title: Insulin-like growth factor receptor signaling in breast tumor epithelium protects cells from endoplasmic reticulum stress and regulates the tumor microenvironment
    Article Snippet: IMC-A12 (10 mg/ml), a monoclonal antibody against IGF-1R, was provided by ImClone Systems, a wholly owned subsidiary of Eli Lilly and Co. Human IgG antibody (31154; 11.3 mg/ml), a monoclonal antibody used as a control, was purchased from Invitrogen.

    Article Title: Chemotherapy and targeted agents for thymic malignancies.
    Article Snippet: www.expert-reviews.com ISSN 1473-7140 © 2012 Expert Reviews Ltd 10.1586/ERA.12.29 Thymic malignancies represent a wide range of clinical, histologic and molecular entities that may be aggressive and difficult to treat [1–4].. The current histopathologic classification distinguishes thymomas (types A, AB, B1, B2 and B3) and thymic carcinoma based upon the morphology of epithelial tumor cells (with an increasing degree of atypia from type A to thymic carcinoma), the relative proportion of the nontumoral lymphocytic component (decreasing from types B1 to B3) and resemblance to normal thymic architecture [2].. Tumor invasiveness as evaluated by the Masaoka staging system is a major predictor of outcome [5,6].

    Article Title: Combination drug therapy for the treatment of solid tumors
    Article Snippet: 11:944s-950s; or being developed by Imclone (e.g., IMC-A12), or ganitumab, an anti-IGF1R antibody (Amgen), as described in “RECOMMENDED International Nonproprietary Names: List 65,” published by the World Health Organization, Avenue Appia 2, 1211 Geneva 27, Switzerland; R1507, an anti-IGF1R antibody (Genmab/Roche); AVE-1642, an anti-IGF1R antibody (Immunogen/Sanofi-Aventis); MK 0646 or h7C10, an anti-IGF1R antibody (Merck); or antibodies being develop by Schering-Plough Research Institute (e.g., SCH 717454 or 19D12; or as described in US Patent Application Publication Nos.

    Article Title: Insulin-like Growth Factor-II (IGF-II) and IGF-II Analogs with Enhanced Insulin Receptor-a Binding Affinity Promote Neural Stem Cell Expansion
    Article Snippet: In some experiments, the functional blocking antibody, IMC-A12, a monoclonal antibody against IGF-1R was used (provided by ImClone Systems, a wholly owned subsidiary of Eli Lilly and Co).

    Article Title: Compositions for the treatment of solid tumors
    Article Snippet: 11:944s-950s; or being developed by Imclone (e.g., IMC-A12), or ganitumab, an anti-IGF1R antibody (Amgen), as described in “RECOMMENDED International Nonproprietary: Names: List 65,” published by the World Health Organization, Avenue Appia 2, 1211 Geneva 27, Switzerland; R1507, an anti-IGF1R antibody (Genmab/Roche); AVE-1642, an anti-IGF1R antibody (Immunogen/Sanofi-Aventis); MK 0646 or h7C10, an anti-IGF1R antibody (Merck); or antibodies being develop by Schering-Plough Research Institute (e.g., SCH 717454 or 19D12; or as described in US Patent Application Publication Nos.

    Article Title: Circulating tumor cell assay
    Article Snippet: Other preferred anti-IGF-1R antibodies include F-50035 and MK-0646 (Pierre Fabre/Merck); 19D12 (Schering-Plough); R1507 (Roche/Genmab); EM-164/AVE-1642 (Immunogen/Sanofi-Aventis); IMC-A12 (ImClone Systems); AMG479 (Amgen); as well as antibodies described in International Patent Application No. WO2006/069202; U.S. Patent Application Publication No. 2005/0147612; U.S. Patent Application Publication No. 2005/0084906; U.S. Patent Application Publication No. 2005/0249730; U.S. Patent Application Publication No. 2004/0018191; U.S. Patent Application Publication No. 2005/0136063; U.S. Patent Application Publication No. 2003/0235582; U.S. Patent Application Publication No. 2004/0265307; U.S. Patent Application Publication No. 2004/0228859; U.S. Patent Application Publication No. 2005/0008642; European Patent Application No. 1622942; U.S. Patent Application Publication No. 2003/0165502; and U.S. Patent Publication No. 2005/0048050.

    Article Title: The Pathophysiology of Thyroid Eye Disease (TED): Implications for Immunotherapy
    Article Snippet: Figitumumab (CP-751,871) is a blocking anti-IGF-1R antibody currently undergoing phase III clinical trials in patients with non-small cell lung cancers, and IMC-A12 (Imclone), a human monoclonal antibody against IGF-1R, which has also shown promise in the treatment of other IGF-1R bearing neoplasms [ 49 , 50 ].

    Activity Assay:

    Article Title: Insulin-like growth factor receptor signaling in breast tumor epithelium protects cells from endoplasmic reticulum stress and regulates the tumor microenvironment
    Article Snippet: IMC-A12 (10 mg/ml), a monoclonal antibody against IGF-1R, was provided by ImClone Systems, a wholly owned subsidiary of Eli Lilly and Co. Human IgG antibody (31154; 11.3 mg/ml), a monoclonal antibody used as a control, was purchased from Invitrogen.

    Article Title: Chemotherapy and targeted agents for thymic malignancies.
    Article Snippet: www.expert-reviews.com ISSN 1473-7140 © 2012 Expert Reviews Ltd 10.1586/ERA.12.29 Thymic malignancies represent a wide range of clinical, histologic and molecular entities that may be aggressive and difficult to treat [1–4].. The current histopathologic classification distinguishes thymomas (types A, AB, B1, B2 and B3) and thymic carcinoma based upon the morphology of epithelial tumor cells (with an increasing degree of atypia from type A to thymic carcinoma), the relative proportion of the nontumoral lymphocytic component (decreasing from types B1 to B3) and resemblance to normal thymic architecture [2].. Tumor invasiveness as evaluated by the Masaoka staging system is a major predictor of outcome [5,6].

    Article Title: Combination drug therapy for the treatment of solid tumors
    Article Snippet: 11:944s-950s; or being developed by Imclone (e.g., IMC-A12), or ganitumab, an anti-IGF1R antibody (Amgen), as described in “RECOMMENDED International Nonproprietary Names: List 65,” published by the World Health Organization, Avenue Appia 2, 1211 Geneva 27, Switzerland; R1507, an anti-IGF1R antibody (Genmab/Roche); AVE-1642, an anti-IGF1R antibody (Immunogen/Sanofi-Aventis); MK 0646 or h7C10, an anti-IGF1R antibody (Merck); or antibodies being develop by Schering-Plough Research Institute (e.g., SCH 717454 or 19D12; or as described in US Patent Application Publication Nos.

    Article Title: Insulin-like Growth Factor-II (IGF-II) and IGF-II Analogs with Enhanced Insulin Receptor-a Binding Affinity Promote Neural Stem Cell Expansion
    Article Snippet: In some experiments, the functional blocking antibody, IMC-A12, a monoclonal antibody against IGF-1R was used (provided by ImClone Systems, a wholly owned subsidiary of Eli Lilly and Co).

    Article Title: Compositions for the treatment of solid tumors
    Article Snippet: 11:944s-950s; or being developed by Imclone (e.g., IMC-A12), or ganitumab, an anti-IGF1R antibody (Amgen), as described in “RECOMMENDED International Nonproprietary: Names: List 65,” published by the World Health Organization, Avenue Appia 2, 1211 Geneva 27, Switzerland; R1507, an anti-IGF1R antibody (Genmab/Roche); AVE-1642, an anti-IGF1R antibody (Immunogen/Sanofi-Aventis); MK 0646 or h7C10, an anti-IGF1R antibody (Merck); or antibodies being develop by Schering-Plough Research Institute (e.g., SCH 717454 or 19D12; or as described in US Patent Application Publication Nos.

    Article Title: Circulating tumor cell assay
    Article Snippet: Other preferred anti-IGF-1R antibodies include F-50035 and MK-0646 (Pierre Fabre/Merck); 19D12 (Schering-Plough); R1507 (Roche/Genmab); EM-164/AVE-1642 (Immunogen/Sanofi-Aventis); IMC-A12 (ImClone Systems); AMG479 (Amgen); as well as antibodies described in International Patent Application No. WO2006/069202; U.S. Patent Application Publication No. 2005/0147612; U.S. Patent Application Publication No. 2005/0084906; U.S. Patent Application Publication No. 2005/0249730; U.S. Patent Application Publication No. 2004/0018191; U.S. Patent Application Publication No. 2005/0136063; U.S. Patent Application Publication No. 2003/0235582; U.S. Patent Application Publication No. 2004/0265307; U.S. Patent Application Publication No. 2004/0228859; U.S. Patent Application Publication No. 2005/0008642; European Patent Application No. 1622942; U.S. Patent Application Publication No. 2003/0165502; and U.S. Patent Publication No. 2005/0048050.

    Article Title: The Pathophysiology of Thyroid Eye Disease (TED): Implications for Immunotherapy
    Article Snippet: Figitumumab (CP-751,871) is a blocking anti-IGF-1R antibody currently undergoing phase III clinical trials in patients with non-small cell lung cancers, and IMC-A12 (Imclone), a human monoclonal antibody against IGF-1R, which has also shown promise in the treatment of other IGF-1R bearing neoplasms [ 49 , 50 ].

    In Vitro:

    Article Title: Insulin-like growth factor receptor signaling in breast tumor epithelium protects cells from endoplasmic reticulum stress and regulates the tumor microenvironment
    Article Snippet: IMC-A12 (10 mg/ml), a monoclonal antibody against IGF-1R, was provided by ImClone Systems, a wholly owned subsidiary of Eli Lilly and Co. Human IgG antibody (31154; 11.3 mg/ml), a monoclonal antibody used as a control, was purchased from Invitrogen.

    Article Title: Chemotherapy and targeted agents for thymic malignancies.
    Article Snippet: www.expert-reviews.com ISSN 1473-7140 © 2012 Expert Reviews Ltd 10.1586/ERA.12.29 Thymic malignancies represent a wide range of clinical, histologic and molecular entities that may be aggressive and difficult to treat [1–4].. The current histopathologic classification distinguishes thymomas (types A, AB, B1, B2 and B3) and thymic carcinoma based upon the morphology of epithelial tumor cells (with an increasing degree of atypia from type A to thymic carcinoma), the relative proportion of the nontumoral lymphocytic component (decreasing from types B1 to B3) and resemblance to normal thymic architecture [2].. Tumor invasiveness as evaluated by the Masaoka staging system is a major predictor of outcome [5,6].

    Article Title: Combination drug therapy for the treatment of solid tumors
    Article Snippet: 11:944s-950s; or being developed by Imclone (e.g., IMC-A12), or ganitumab, an anti-IGF1R antibody (Amgen), as described in “RECOMMENDED International Nonproprietary Names: List 65,” published by the World Health Organization, Avenue Appia 2, 1211 Geneva 27, Switzerland; R1507, an anti-IGF1R antibody (Genmab/Roche); AVE-1642, an anti-IGF1R antibody (Immunogen/Sanofi-Aventis); MK 0646 or h7C10, an anti-IGF1R antibody (Merck); or antibodies being develop by Schering-Plough Research Institute (e.g., SCH 717454 or 19D12; or as described in US Patent Application Publication Nos.

    Article Title: Insulin-like Growth Factor-II (IGF-II) and IGF-II Analogs with Enhanced Insulin Receptor-a Binding Affinity Promote Neural Stem Cell Expansion
    Article Snippet: In some experiments, the functional blocking antibody, IMC-A12, a monoclonal antibody against IGF-1R was used (provided by ImClone Systems, a wholly owned subsidiary of Eli Lilly and Co).

    Article Title: Compositions for the treatment of solid tumors
    Article Snippet: 11:944s-950s; or being developed by Imclone (e.g., IMC-A12), or ganitumab, an anti-IGF1R antibody (Amgen), as described in “RECOMMENDED International Nonproprietary: Names: List 65,” published by the World Health Organization, Avenue Appia 2, 1211 Geneva 27, Switzerland; R1507, an anti-IGF1R antibody (Genmab/Roche); AVE-1642, an anti-IGF1R antibody (Immunogen/Sanofi-Aventis); MK 0646 or h7C10, an anti-IGF1R antibody (Merck); or antibodies being develop by Schering-Plough Research Institute (e.g., SCH 717454 or 19D12; or as described in US Patent Application Publication Nos.

    Article Title: Circulating tumor cell assay
    Article Snippet: Other preferred anti-IGF-1R antibodies include F-50035 and MK-0646 (Pierre Fabre/Merck); 19D12 (Schering-Plough); R1507 (Roche/Genmab); EM-164/AVE-1642 (Immunogen/Sanofi-Aventis); IMC-A12 (ImClone Systems); AMG479 (Amgen); as well as antibodies described in International Patent Application No. WO2006/069202; U.S. Patent Application Publication No. 2005/0147612; U.S. Patent Application Publication No. 2005/0084906; U.S. Patent Application Publication No. 2005/0249730; U.S. Patent Application Publication No. 2004/0018191; U.S. Patent Application Publication No. 2005/0136063; U.S. Patent Application Publication No. 2003/0235582; U.S. Patent Application Publication No. 2004/0265307; U.S. Patent Application Publication No. 2004/0228859; U.S. Patent Application Publication No. 2005/0008642; European Patent Application No. 1622942; U.S. Patent Application Publication No. 2003/0165502; and U.S. Patent Publication No. 2005/0048050.

    Article Title: The Pathophysiology of Thyroid Eye Disease (TED): Implications for Immunotherapy
    Article Snippet: Figitumumab (CP-751,871) is a blocking anti-IGF-1R antibody currently undergoing phase III clinical trials in patients with non-small cell lung cancers, and IMC-A12 (Imclone), a human monoclonal antibody against IGF-1R, which has also shown promise in the treatment of other IGF-1R bearing neoplasms [ 49 , 50 ].

    Functional Assay:

    Article Title: Insulin-like growth factor receptor signaling in breast tumor epithelium protects cells from endoplasmic reticulum stress and regulates the tumor microenvironment
    Article Snippet: IMC-A12 (10 mg/ml), a monoclonal antibody against IGF-1R, was provided by ImClone Systems, a wholly owned subsidiary of Eli Lilly and Co. Human IgG antibody (31154; 11.3 mg/ml), a monoclonal antibody used as a control, was purchased from Invitrogen.

    Article Title: Chemotherapy and targeted agents for thymic malignancies.
    Article Snippet: www.expert-reviews.com ISSN 1473-7140 © 2012 Expert Reviews Ltd 10.1586/ERA.12.29 Thymic malignancies represent a wide range of clinical, histologic and molecular entities that may be aggressive and difficult to treat [1–4].. The current histopathologic classification distinguishes thymomas (types A, AB, B1, B2 and B3) and thymic carcinoma based upon the morphology of epithelial tumor cells (with an increasing degree of atypia from type A to thymic carcinoma), the relative proportion of the nontumoral lymphocytic component (decreasing from types B1 to B3) and resemblance to normal thymic architecture [2].. Tumor invasiveness as evaluated by the Masaoka staging system is a major predictor of outcome [5,6].

    Article Title: Combination drug therapy for the treatment of solid tumors
    Article Snippet: 11:944s-950s; or being developed by Imclone (e.g., IMC-A12), or ganitumab, an anti-IGF1R antibody (Amgen), as described in “RECOMMENDED International Nonproprietary Names: List 65,” published by the World Health Organization, Avenue Appia 2, 1211 Geneva 27, Switzerland; R1507, an anti-IGF1R antibody (Genmab/Roche); AVE-1642, an anti-IGF1R antibody (Immunogen/Sanofi-Aventis); MK 0646 or h7C10, an anti-IGF1R antibody (Merck); or antibodies being develop by Schering-Plough Research Institute (e.g., SCH 717454 or 19D12; or as described in US Patent Application Publication Nos.

    Article Title: Insulin-like Growth Factor-II (IGF-II) and IGF-II Analogs with Enhanced Insulin Receptor-a Binding Affinity Promote Neural Stem Cell Expansion
    Article Snippet: In some experiments, the functional blocking antibody, IMC-A12, a monoclonal antibody against IGF-1R was used (provided by ImClone Systems, a wholly owned subsidiary of Eli Lilly and Co).

    Article Title: Compositions for the treatment of solid tumors
    Article Snippet: 11:944s-950s; or being developed by Imclone (e.g., IMC-A12), or ganitumab, an anti-IGF1R antibody (Amgen), as described in “RECOMMENDED International Nonproprietary: Names: List 65,” published by the World Health Organization, Avenue Appia 2, 1211 Geneva 27, Switzerland; R1507, an anti-IGF1R antibody (Genmab/Roche); AVE-1642, an anti-IGF1R antibody (Immunogen/Sanofi-Aventis); MK 0646 or h7C10, an anti-IGF1R antibody (Merck); or antibodies being develop by Schering-Plough Research Institute (e.g., SCH 717454 or 19D12; or as described in US Patent Application Publication Nos.

    Article Title: Circulating tumor cell assay
    Article Snippet: Other preferred anti-IGF-1R antibodies include F-50035 and MK-0646 (Pierre Fabre/Merck); 19D12 (Schering-Plough); R1507 (Roche/Genmab); EM-164/AVE-1642 (Immunogen/Sanofi-Aventis); IMC-A12 (ImClone Systems); AMG479 (Amgen); as well as antibodies described in International Patent Application No. WO2006/069202; U.S. Patent Application Publication No. 2005/0147612; U.S. Patent Application Publication No. 2005/0084906; U.S. Patent Application Publication No. 2005/0249730; U.S. Patent Application Publication No. 2004/0018191; U.S. Patent Application Publication No. 2005/0136063; U.S. Patent Application Publication No. 2003/0235582; U.S. Patent Application Publication No. 2004/0265307; U.S. Patent Application Publication No. 2004/0228859; U.S. Patent Application Publication No. 2005/0008642; European Patent Application No. 1622942; U.S. Patent Application Publication No. 2003/0165502; and U.S. Patent Publication No. 2005/0048050.

    Article Title: The Pathophysiology of Thyroid Eye Disease (TED): Implications for Immunotherapy
    Article Snippet: Figitumumab (CP-751,871) is a blocking anti-IGF-1R antibody currently undergoing phase III clinical trials in patients with non-small cell lung cancers, and IMC-A12 (Imclone), a human monoclonal antibody against IGF-1R, which has also shown promise in the treatment of other IGF-1R bearing neoplasms [ 49 , 50 ].

    Blocking Assay:

    Article Title: Insulin-like growth factor receptor signaling in breast tumor epithelium protects cells from endoplasmic reticulum stress and regulates the tumor microenvironment
    Article Snippet: IMC-A12 (10 mg/ml), a monoclonal antibody against IGF-1R, was provided by ImClone Systems, a wholly owned subsidiary of Eli Lilly and Co. Human IgG antibody (31154; 11.3 mg/ml), a monoclonal antibody used as a control, was purchased from Invitrogen.

    Article Title: Chemotherapy and targeted agents for thymic malignancies.
    Article Snippet: www.expert-reviews.com ISSN 1473-7140 © 2012 Expert Reviews Ltd 10.1586/ERA.12.29 Thymic malignancies represent a wide range of clinical, histologic and molecular entities that may be aggressive and difficult to treat [1–4].. The current histopathologic classification distinguishes thymomas (types A, AB, B1, B2 and B3) and thymic carcinoma based upon the morphology of epithelial tumor cells (with an increasing degree of atypia from type A to thymic carcinoma), the relative proportion of the nontumoral lymphocytic component (decreasing from types B1 to B3) and resemblance to normal thymic architecture [2].. Tumor invasiveness as evaluated by the Masaoka staging system is a major predictor of outcome [5,6].

    Article Title: Combination drug therapy for the treatment of solid tumors
    Article Snippet: 11:944s-950s; or being developed by Imclone (e.g., IMC-A12), or ganitumab, an anti-IGF1R antibody (Amgen), as described in “RECOMMENDED International Nonproprietary Names: List 65,” published by the World Health Organization, Avenue Appia 2, 1211 Geneva 27, Switzerland; R1507, an anti-IGF1R antibody (Genmab/Roche); AVE-1642, an anti-IGF1R antibody (Immunogen/Sanofi-Aventis); MK 0646 or h7C10, an anti-IGF1R antibody (Merck); or antibodies being develop by Schering-Plough Research Institute (e.g., SCH 717454 or 19D12; or as described in US Patent Application Publication Nos.

    Article Title: Insulin-like Growth Factor-II (IGF-II) and IGF-II Analogs with Enhanced Insulin Receptor-a Binding Affinity Promote Neural Stem Cell Expansion
    Article Snippet: In some experiments, the functional blocking antibody, IMC-A12, a monoclonal antibody against IGF-1R was used (provided by ImClone Systems, a wholly owned subsidiary of Eli Lilly and Co).

    Article Title: Compositions for the treatment of solid tumors
    Article Snippet: 11:944s-950s; or being developed by Imclone (e.g., IMC-A12), or ganitumab, an anti-IGF1R antibody (Amgen), as described in “RECOMMENDED International Nonproprietary: Names: List 65,” published by the World Health Organization, Avenue Appia 2, 1211 Geneva 27, Switzerland; R1507, an anti-IGF1R antibody (Genmab/Roche); AVE-1642, an anti-IGF1R antibody (Immunogen/Sanofi-Aventis); MK 0646 or h7C10, an anti-IGF1R antibody (Merck); or antibodies being develop by Schering-Plough Research Institute (e.g., SCH 717454 or 19D12; or as described in US Patent Application Publication Nos.

    Article Title: Circulating tumor cell assay
    Article Snippet: Other preferred anti-IGF-1R antibodies include F-50035 and MK-0646 (Pierre Fabre/Merck); 19D12 (Schering-Plough); R1507 (Roche/Genmab); EM-164/AVE-1642 (Immunogen/Sanofi-Aventis); IMC-A12 (ImClone Systems); AMG479 (Amgen); as well as antibodies described in International Patent Application No. WO2006/069202; U.S. Patent Application Publication No. 2005/0147612; U.S. Patent Application Publication No. 2005/0084906; U.S. Patent Application Publication No. 2005/0249730; U.S. Patent Application Publication No. 2004/0018191; U.S. Patent Application Publication No. 2005/0136063; U.S. Patent Application Publication No. 2003/0235582; U.S. Patent Application Publication No. 2004/0265307; U.S. Patent Application Publication No. 2004/0228859; U.S. Patent Application Publication No. 2005/0008642; European Patent Application No. 1622942; U.S. Patent Application Publication No. 2003/0165502; and U.S. Patent Publication No. 2005/0048050.

    Article Title: The Pathophysiology of Thyroid Eye Disease (TED): Implications for Immunotherapy
    Article Snippet: Figitumumab (CP-751,871) is a blocking anti-IGF-1R antibody currently undergoing phase III clinical trials in patients with non-small cell lung cancers, and IMC-A12 (Imclone), a human monoclonal antibody against IGF-1R, which has also shown promise in the treatment of other IGF-1R bearing neoplasms [ 49 , 50 ].

    Clinical Proteomics:

    Article Title: Insulin-like growth factor receptor signaling in breast tumor epithelium protects cells from endoplasmic reticulum stress and regulates the tumor microenvironment
    Article Snippet: IMC-A12 (10 mg/ml), a monoclonal antibody against IGF-1R, was provided by ImClone Systems, a wholly owned subsidiary of Eli Lilly and Co. Human IgG antibody (31154; 11.3 mg/ml), a monoclonal antibody used as a control, was purchased from Invitrogen.

    Article Title: Chemotherapy and targeted agents for thymic malignancies.
    Article Snippet: www.expert-reviews.com ISSN 1473-7140 © 2012 Expert Reviews Ltd 10.1586/ERA.12.29 Thymic malignancies represent a wide range of clinical, histologic and molecular entities that may be aggressive and difficult to treat [1–4].. The current histopathologic classification distinguishes thymomas (types A, AB, B1, B2 and B3) and thymic carcinoma based upon the morphology of epithelial tumor cells (with an increasing degree of atypia from type A to thymic carcinoma), the relative proportion of the nontumoral lymphocytic component (decreasing from types B1 to B3) and resemblance to normal thymic architecture [2].. Tumor invasiveness as evaluated by the Masaoka staging system is a major predictor of outcome [5,6].

    Article Title: Combination drug therapy for the treatment of solid tumors
    Article Snippet: 11:944s-950s; or being developed by Imclone (e.g., IMC-A12), or ganitumab, an anti-IGF1R antibody (Amgen), as described in “RECOMMENDED International Nonproprietary Names: List 65,” published by the World Health Organization, Avenue Appia 2, 1211 Geneva 27, Switzerland; R1507, an anti-IGF1R antibody (Genmab/Roche); AVE-1642, an anti-IGF1R antibody (Immunogen/Sanofi-Aventis); MK 0646 or h7C10, an anti-IGF1R antibody (Merck); or antibodies being develop by Schering-Plough Research Institute (e.g., SCH 717454 or 19D12; or as described in US Patent Application Publication Nos.

    Article Title: Insulin-like Growth Factor-II (IGF-II) and IGF-II Analogs with Enhanced Insulin Receptor-a Binding Affinity Promote Neural Stem Cell Expansion
    Article Snippet: In some experiments, the functional blocking antibody, IMC-A12, a monoclonal antibody against IGF-1R was used (provided by ImClone Systems, a wholly owned subsidiary of Eli Lilly and Co).

    Article Title: Compositions for the treatment of solid tumors
    Article Snippet: 11:944s-950s; or being developed by Imclone (e.g., IMC-A12), or ganitumab, an anti-IGF1R antibody (Amgen), as described in “RECOMMENDED International Nonproprietary: Names: List 65,” published by the World Health Organization, Avenue Appia 2, 1211 Geneva 27, Switzerland; R1507, an anti-IGF1R antibody (Genmab/Roche); AVE-1642, an anti-IGF1R antibody (Immunogen/Sanofi-Aventis); MK 0646 or h7C10, an anti-IGF1R antibody (Merck); or antibodies being develop by Schering-Plough Research Institute (e.g., SCH 717454 or 19D12; or as described in US Patent Application Publication Nos.

    Article Title: Circulating tumor cell assay
    Article Snippet: Other preferred anti-IGF-1R antibodies include F-50035 and MK-0646 (Pierre Fabre/Merck); 19D12 (Schering-Plough); R1507 (Roche/Genmab); EM-164/AVE-1642 (Immunogen/Sanofi-Aventis); IMC-A12 (ImClone Systems); AMG479 (Amgen); as well as antibodies described in International Patent Application No. WO2006/069202; U.S. Patent Application Publication No. 2005/0147612; U.S. Patent Application Publication No. 2005/0084906; U.S. Patent Application Publication No. 2005/0249730; U.S. Patent Application Publication No. 2004/0018191; U.S. Patent Application Publication No. 2005/0136063; U.S. Patent Application Publication No. 2003/0235582; U.S. Patent Application Publication No. 2004/0265307; U.S. Patent Application Publication No. 2004/0228859; U.S. Patent Application Publication No. 2005/0008642; European Patent Application No. 1622942; U.S. Patent Application Publication No. 2003/0165502; and U.S. Patent Publication No. 2005/0048050.

    Article Title: The Pathophysiology of Thyroid Eye Disease (TED): Implications for Immunotherapy
    Article Snippet: Figitumumab (CP-751,871) is a blocking anti-IGF-1R antibody currently undergoing phase III clinical trials in patients with non-small cell lung cancers, and IMC-A12 (Imclone), a human monoclonal antibody against IGF-1R, which has also shown promise in the treatment of other IGF-1R bearing neoplasms [ 49 , 50 ].



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    Image Search Results


    Clinical trials on targeted therapy in hepatocellular carcinoma recurrence.

    Journal: Current Oncology

    Article Title: Potential Molecular Targeted Therapy for Unresectable Hepatocellular Carcinoma

    doi: 10.3390/curroncol30020105

    Figure Lengend Snippet: Clinical trials on targeted therapy in hepatocellular carcinoma recurrence.

    Article Snippet: Recombinant human IgG1 monoclonal antibody cixutumumab (formerly IMC-A12, ImClone Systems, Inc, Bridgewater, NJ, USA) is aimed at IGF-1R.

    Techniques: Clinical Proteomics, Virus, Infection